Barbiturates cause poor coordination, slurred speech, and decreased alertness. One who uses barbiturates on a regular basis may be sleepy, irritable, and confused. A habitual barbiturates user, upon withdrawal, may experience convulsions, nausea, breathing difficulty, insomnia, hallucinations, tremors, and even death.
Tranquilizers cause blurred vision, dizziness, slurred speech, drowsiness, headache, and skin rash, and long-term side effects are blood and liver disease. A person withdrawing from tranquilizers will be anxious and nauseous, and have cramps and diarrhea.
Marijuana, including hashish, causes panic, memory loss, distorted perception, anxiety, increased heart rate, decrease in muscle strength, impaired motorkills, and vomiting. Habitual marijuana use causes lung cancer, bronchitis, respiratory tract irritation, and possible fetal damage. A person withdrawing from marijuana will be irritable and restless. They will have trouble sleeping, lose weight, and have a decreased appetite. 
It's not just a cliché, do yourself a favor and don't start, or quit now.
 Many "Christians" use marijuana, but this is a violation of the commands of scripture (and common sense). See http://Godandscience.org/doctrine/marijuana.html.